What is the mechanism by which the AIDS virus causes deficiency of immune system of the infected person?
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Upon managing to enter the body, this virus enters into macrophages, where the RNA genome of the virus duplicates for the formation of viral DNA by the action of the reverse transcriptase enzyme. The viral DNA is then incorporated into the DNA of the cells of the host, which targets the infected cells to synthesize virus particles. The macrophages continue to produce the virus, serving as an HIV factory. On the other hand, HIV enters the helper T-lymphocytes, replicating and producing progeny viruses, which when released in the blood, target other helper T-lymphocytes, which is reiterated, causing a progressive decrease in the count of helper T-lymphocytes in the patient’s body. In the long run, there is a significant decline in the count of helper T-lymphocytes resulting in the weakening of the defence mechanism of the body. This is referred to as acquired immunodeficiency.