Define the oxygen dissociation curve. Can you suggest any reason for its sigmoidal pattern?
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Ans. The oxygen dissociation curve is a graph showing the percentage saturation of oxyhemoglobin at various partial pressures of oxygen.
Oxygen Dissociation Curve
The curve shows us the equilibrium of oxyhemoglobin and hemoglobin at different partial pressures.
The partial pressure of oxygen in the lungs is high, so hemoglobin binds to oxygen and forms oxyhemoglobin.
Tissues have low levels of oxygen, so oxyhemoglobin releases oxygen in tissues to form hemoglobin.
The sigmoid form of the dissociation curve is due to the binding of oxygen to hemoglobin. As the first oxygen molecule binds to hemoglobin, the binding affinity of the second oxygen molecule increases. The hemoglobin then attracts more oxygen.