Ans: Let the equation of the required circle be ${{(x-h)}^{2}}+{{(y-k)}^{2}}={{r}^{2}}$
Since the circle passes through points $(4,1)$ and $(6,5)$,
${{(4-h)}^{2}}+{{(1-k)}^{2}}={{r}^{2}}$ ………(i)
${{(6-h)}^{2}}+{{(5-k)}^{2}}={{r}^{2}}$ ………(ii)
Since the centre (h,k) of the circle lies on line $4x+y=16,$
$4h+k=16$ ………(iii)
From equations (i) and (ii), we get
$\Rightarrow {{(4-h)}^{2}}+{{(1-k)}^{2}}={{(6-h)}^{2}}+{{(5-k)}^{2}}$
$\Rightarrow 16-8h+{{h}^{2}}+1-2k+{{k}^{2}}=36-12h+{{h}^{2}}+25-10k+{{k}^{2}}$
$\begin{align} & \Rightarrow 16-8h+1-2k=36-12h+25-10k \\ & \Rightarrow 4h+8k=44 \\ \end{align}$
$\Rightarrow h+2k=11$ ………(iv)
On solving equations (iii) and (iv), we obtain $h=3$ and $k=4$
On substituting the values of h and k in equation (i), we obtain
${{(4-3)}^{2}}+{{(1-4)}^{2}}={{r}^{2}}$
$\Rightarrow {{(1)}^{2}}+{{(-3)}^{2}}={{r}^{2}}$
$\Rightarrow 1+9={{r}^{2}}$
$\begin{align} & \Rightarrow {{r}^{2}}=10 \\ & \Rightarrow r=\sqrt{10} \\ \end{align}$
Thus, the equation of the required circle is
${{(x-3)}^{2}}+{{(y-4)}^{2}}={{\left( \sqrt{10} \right)}^{2}}$
$\begin{align} & {{x}^{2}}-6x+9+{{y}^{2}}-8y+16=10 \\ & {{x}^{2}}+{{y}^{2}}-6x-8y+15=0 \\ \end{align}$