Cellular and Humoral Immunity - Parasitology and Immunology - Life Sciences Previous Year Questions

1

2007 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2007

Systemic lupus erythematosus (SLE), an autoimmune disease, is characterized by the presence of

A

Anti-DNA antibodies

B

Anti-thyroglobulin antibodies

C

Anti-insulin antibodies

D

Anti-collagen antibodies

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2

2007 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2007

In addition to adjuvants, generation of anti-hapten antibodies will require injection of

A

the hapten to a mice

B

a mixture of hapten and protein to a mice

C

the hapten covalently linked to a protein to a mice

D

a mixture of hapten and lipid to a mice

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3

2007 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2007

Which type of cells actually secrete antibodies?

A

T cells

B

Macrophages

C

Monocytes

D

Plasma cells

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4

2007 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2007

Each individual antigenic determinant of the variable region of the antibody is referred to as

A

Paratope

B

Epitope

C

Agretope

D

Idiotope

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5

2007 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2007

Rajesh and Deb while playing in the field got stung by a comparable number of bees. About after 15 minutes, while Rajesh experienced only pain and small swelling, Deb manifested intense swelling, breathlessness and had to be hospitalized. Which of the following reasons would be the most logical explanation for the different reactions ?

A

Deb was on an empty stomach

B

Rajesh is several years younger than Deb

C

Deb had been stung by bees before

D

Deb is several years younger than Rajesh

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6

2007 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2007

Which of the following class of antibodies would be detected in these strains of mice on day 7 ?

A

IgM (b) IgM (n)

B

IgG (b) IgM (n)

C

IgA (b) IgM (n)

D

IgE (b) IgM (n)

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7

2007 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2007

Which of the following class of antibodies would be detected in the two strains of mice on day 18 ?

A

IgG (b) IgM (n)

B

IgE (b) IgE (n)

C

IgE (b) IgE (n)

D

IgE (b) IgG (n)

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8

2008 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2008

One common feature between B and T cells is that

A

both cells produce antibodies

B

both cells possess MHC class II

C

both B cell receptor and T cell receptor undergo rearrangement

D

both cells can produce cytokines

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9

2008 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2008

Nucleated cells tends to be more resistant to complement mediated lysis than RBC because

A

many nucleated cells can endocytose the membrane attack complex

B

membrane attack complex cannot get inserted in the nucleated cell membrane

C

membrane attack complex can get inactivated by the nucleated cells

D

membrane attack complex get inactivated hence cannot get inserted in the nucleated cell membrane

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10

2008 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2008

Serum IgM cannot activate the complement by itself because

A

it does not have complement binding site

B

it is planar in which complement binding sites in the Fc region are not accessible.

C

it gets degraded and hence unable to activate the complement

D

it needs metal ions to activate complement

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11

2009 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2009

Which of these can be an antigen but cannot induce immune responses ?

A

Hemocyanin

B

Influenza virus

C

Azobenzene arsonate

D

Corynebacteria

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12

2009 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2009

In myasthenia gravis, a neuromuscular disorder, the acetylcholine receptor becomes dysfunctional because

A

the receptor is mutated.

B

antibodies to the receptor inhibit ligand binding.

C

of deficiency in acetylcholine transferase.

D

of excess of acetylcholine esterase.

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13

2009 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2009

The human immune system is able to mount a response when it encounters a novel microorganism for the first time because

A

White blood cells are able to change their antigen specificity depending upon the microorganism they interact with.

B

Our body contains millions of different kinds of white blood cells, each with a unique type of antigen receptor.

C

Bone marrow cells make different antigen receptors depending upon the kind of invading microorganism.

D

Bone marrow cells are able to change their antigen specificity upon physical interaction with the microorganism.

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14

2010 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2010

Positive selection of T cells ensures

A

MHC restriction

B

Self tolerance

C

TCR engagements

D

Activation by co-stimulatory signal

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15

2010 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2010

Match the items in Group 1 with those in Group 2 Group 1: P. Isotype switching, Q. Clonal energy, R. Class II MHC, S. Self tolerance Group 2: 1. V_H domain, 2. Non-responsive to self antigen, 3. Non-responsive T_H cells, 4. β₂-microglobulin

A

P-1, Q-4, R-3, S-2

B

P-2, Q-4, R-1, S-3

C

P-1, Q-3, R-4, S-2

D

P-2, Q-1, R-3, S-4

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16

2010 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2010

Superantigens elicit a very strong T cell response because they

A

bind to the specific antigen binding site on the T cell receptors (TCR)

B

bind to the site on T cell receptor (TCR) that is outside the antigen-specific binding site

C

directly activate the T cell without the help of antigen presenting cells

D

directly induce cytokine secretion by macrophages

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17

2010 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2010

During immune response, helper T-cell memory against the antigen appears earlier than the B memory cells. Which one of the following is the primary reason for this phenomenon?

A

Affinity of antibody molecules produced by B cells is weaker than those of T cells

B

B memory cells proliferate at a rate slower than that of T cells

C

cell activation requires helper T cells

D

Thymic selection more rapidly enhances the T cell population than B cell population

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18

2010 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2010

Which one of the following is most crucial for the success of vaccination?

A

Antigen presentation by T helper cells

B

Complement system

C

Presence of long-lived antigen-specific lymphocytes

D

Selection of B cells in the lymphoid tissue

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19

2011 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2011

The activation of the complement components occurs via three distinct pathways. Which of the following component(s) is specific to the 'Alternate Pathway'?

A

Factor B and D

B

Mannose binding protein

C

C1qr2s2

D

C2

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20

2011 · Life Sciences · Parasitology and Immunology · Cellular and Humoral Immunity

Life Sciences (XL) 2011

Match P, Q, R and S with the appropriate numbers 1 to 6 on the right

A

P) Basophils
Q) T cells
R) B cells
S) Neutrophils
1) Perforin
2) Phagocytosis
3) Albumin
4) Macrogobulin
5) Fc receptors for IgE
6) Plasma cells

B

P-5, Q-1, R-6, S-2

C

P-1, Q-2, R-3, S-4

D

P-3, Q-4, R-5, S-1

E

P-2, Q-6, R-1, S-3

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