Genome Organization, Mutations and Epigenetics - Genetics and Genomics - Life Sciences Previous Year Questions

1

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

Mobile genetic elements present in human genome are (P) long interspersed elements (LINEs) (Q) short interspersed elements (SINEs) (R) P elements (S) IS elements

A

Q, R

B

P, Q

C

P, R

D

Q, S

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2

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

Which vector would be the most appropriate for cloning a 150 kb fragment of DNA?

A

pBR322

B

λ vector

C

YAC

D

BAC

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3

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

Which of the following modes of DNA replication are used by bacteria?

A

Rolling circle

B

Theta replication

C

Bidirectional replication

D

All of the above

Check answer

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4

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

A mutation in the codon UCG to UAG is described as

A

Nonsense mutation

B

Silent mutation

C

Mis-sense mutation

D

Neutral mutation

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5

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

Calculate the percentage of transformed cells

Check answer

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6

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

What is the ratio of genome size of the microorganism relative to average size of the fragment in the gene library?

A

3000

B

1500

C

45000

D

None of these

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7

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

The genomic library was created in vectors that were transformed into bacterial cells. If there is a 95% probability of the transformation, how many recombinant bacterial colonies will have to be screened to find this particular gene?

A

7000

B

8000

C

9000

D

10000

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8

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

Transgenic mice are produced by

A

In vitro fertilization of ova by sperms from a different strain followed by implantation

B

Transfer of cloned foreign DNA into blastocyst cells followed by implantation

C

Implantation of mixed blastocyst cells from two different strains

D

Selection of a given trait by repeated back-crossing

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9

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

Comparison of the genome sequences of any two animals would reveal evolutionary relatedness. In this context, the similarity between man and chimpanzee is

A

> 95 %

B

< 75 %

C

< 25 %

D

< 50%

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10

2007 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2007

Certain types of cancers can be correlated with specific changes in chromosome structure. In patients suffering from myelogenous leukemia, the abnormal chromosome detected was termed Philadelphia chromosome. Which of the following chromosome is altered in this disease ?

A

Chromosome 10

B

Chromosome 11

C

Chromosome 20

D

Chromosome 22

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11

2008 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2008

Both pBR322-x and pUC18-y will hybridize to cosmids

A

b

B

d

C

e

D

c

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12

2008 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2008

Match the terms in group 1 with their possible explanations in group 2

Group 1	Group 2
P. Orthologs	1. A cell or an organism having foreign gene
Q. Paralogs	2. The complement of a protein expressed by a genome
R. Proteome	3. Genes from different species related to each other
S. Transgenic	4. Genes from same species related to each other

A

P-2, Q-4, R-1, S-3

B

P-4, Q-3, R-2, S-1

C

P-3, Q-4, R-2, S-1

D

P-1, Q-2, R-3, S-4

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13

2008 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2008

Genome sequencing of rice will help to

A

Characterize genes present in the rice genome

B

Validate the genes available in other plants

C

Control agri-business

D

Control rice germplasm

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14

2009 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2009

Which of the following statements are TRUE for transposable genetic elements ?
P. IS elements can be inserted at many different sites in bacterial chromosomes and plasmids.
Q. In Tn5 the flanking IS elements are in the same orientation.
R. The Ac and Ds elements in maize were discovered by Barbara McClintock.
S. Tn10 consists of two IS elements flanking a gene for streptomycin resistance.

A

P, Q

B

P, R

C

P, S

D

R, S

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15

2009 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2009

Which of the following scientists are associated with the discoveries listed below ?
1. Identification of DNA as the genetic material    a. Fleming
2. Discovery of penicillin    b. Avery
3. Demonstration of bacterial transformation    c. Beijerinck
4. Demonstration of filterable infectious agent    d. Griffith

A

1-b,2-a,3-d,4-c

B

1-b,2-c,3-a,4-d

C

1-b,2-d,3-a,4-c

D

1-b,2-a,3-c,4-d

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16

2009 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2009

A silent mutation is one that

A

results in a truncated polypeptide

B

replaces an amino acid with an equivalent amino acid in a polypeptide

C

does not change the amino acid sequence of the polypeptide

D

changes the reading frame of the mRNA leading to an altered polypeptide

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17

2010 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2010

When changes in the phenotype or gene expression occur without changes in the underlying DNA sequence, the phenomenon is called

A

Mutation

B

Eugenics

C

Epigenetics

D

Epistasis

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18

2011 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2011

Choose the most appropriate word from the options given below to complete the following sentence:
Under ethical guidelines recently adopted by the Indian Medical Association, human genes are to be manipulated only to correct diseases for which __________ treatments are unsatisfactory.

A

similar

B

most

C

uncommon

D

available

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19

2011 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2011

The mutagen ethidium bromide acts as a

A

Deaminating agent

B

Alkylating agent

C

Intercalating agent

D

Base analogue

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20

2011 · Life Sciences · Genetics and Genomics · Genome Organization, Mutations and Epigenetics

Life Sciences (XL) 2011

Which of the following statements are TRUE for the plastid genomes?
P. Plastid genome is circular in nature with genome size of 120-160 kb
Q. The plastid ribosomes are with sedimentation coefficient of 80S
R. The gene for the small subunit of ribulose bisphosphate carboxylase (RubisCO) is located in the plastid
S. rRNAs in the plastid genome are arranged in one transcription unit

A

P, Q

B

Q, S

C

R, S

D

P, S

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