Cell Signalling and Receptors - Cell Structure and Function - Life Sciences Previous Year Questions

1

2007 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2007

Which of the following hormones binds to a cell surface receptor?

A

Estrogen

B

Thyroid hormone

C

Insulin

D

Aldosterone

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2

2007 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2007

Match the biological functions mentioned in Column A with the enzymes given in Column B.

A	B
(P) Diacylglycerol synthesis	(1) Protein kinase A
(Q) CREB phosphorylation	(2) Ras
(R) GTP hydrolysis	(3) Phospholipase C
	(4) Phospholipase D
	(5) Protein kinase G

A

P-3, Q-1, R-5

B

P-4, Q-1, R-2

C

P-3, Q-1, R-2

D

P-3, Q-5, R-2

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3

2007 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2007

EGF-dependent tyrosine phosphorylation will be detected in

A

Membrane and cytosolic fractions of both the cell lines

B

Only the membrane fraction of only cell line A

C

Only the membrane fraction of both cell lines

D

Only the cytosolic fractions of both cell lines

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4

2007 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2007

EGF-dependent serine phosphorylation will be detected in

A

Membrane and cytosolic fractions of both the cell lines

B

Only the membrane fraction of cell line A

C

Only the membrane fraction of cell line B

D

Only the cytosolic fraction of cell line A

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5

2007 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2007

Normally receptors are cell-membrane bound but with few exceptions. Which of the following receptors is present in the cytoplasm ?

A

Thyroid stimulating hormone receptor

B

Epidermal growth factor receptor

C

Progesterone receptor

D

Cytokine receptor

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6

2008 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2008

Which of the following activate protein kinase C?

A

Inositol 1,4,5-triphosphate

B

Cyclic AMP

C

Inositol

D

Diacylglycerol

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7

2009 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2009

In mammals, the second messenger Nitric Oxide (NO) is produced from

A

Ammonium nitrate

B

Arginine

C

Urea

D

Nitrous acid

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8

2010 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2010

MHC-I groove can be loaded with peptides of only 8-10 amino acids because

A

MHC-I groove is closed on both ends

B

fragments of only 8-10 amino acids are generated in MHC-I bearing cells

C

β2-microglobulin of MHC-I prevents the binding of large peptides to MHC-I

D

β polypeptides of MHC-I prevents binding of 8-10 amino acid long peptides to MHC-I

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9

2010 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2010

As compared to peptide hormones, steroid hormones take more time to activate a cellular response because

A

steroid hormones show non-specific binding with diverse sets of receptors.

B

steroid hormone acts through a receptor which is a transcription factor.

C

cells that respond to steroid hormones are dormant in nature.

D

peptide hormones are not transported through plasma while steroid hormones are.

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10

2011 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2011

Retrograde signaling involves communication of

A

nucleus to the chloroplast

B

endoplasmic reticulum to the nucleus

C

nucleus to the mitochondria

D

chloroplast to the nucleus

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11

2011 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2011

Which of the following statements is/are TRUE about JUXTACRINE signaling?
I. The ligand and the receptor engage in reciprocal signaling
II. Both the ligand and the receptor are membrane associated proteins
III. The ligand gets proteolytically cleaved after binding to the receptor

A

I only

B

II only

C

III only

D

I, II and III

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12

2012 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2012

A typical receptor senses extracellular stimuli by virtue of its localization on plasma membrane. The receptor to which of the following ligands is an exception to this rule?

A

γ-amino butyric acid

B

Acetylcholine

C

Estrogen

D

Luteinizing hormone

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13

2014 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2014

The receptor for epinephrine is a

A

Tyrosine kinase receptor

B

Serine-threonine kinase receptor

C

G-protein-coupled receptor

D

Ligand activated transcription factor

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14

2014 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2014

A newborn was accidentally given a drug that destroyed the thymus. Which ONE of the following would be the most likely outcome?

A

Lack of class I MHC molecules

B

Inability to rearrange antigen receptors

C

Inability to differentiate immature T cells

D

Reduction in T-independent number of B cells

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15

2016 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2016

The primary function of polysaccharides attached to glycoproteins in the animal cell membrane is to

A

Facilitate diffusion of molecules down their concentration gradients.

B

Maintain membrane fluidity at low temperatures.

C

Maintain the integrity of a fluid mosaic membrane.

D

Mediate cell-to-cell recognition.

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16

2017 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2017

The covalent modification performed by kinases which regulate proteins in signaling pathways is

A

glycosylation

B

methylation

C

ubiquitination

D

phosphorylation

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17

2017 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2017

Upon activation of phospholipase C by ligand binding to G-protein coupled receptor, the Ca⁺² concentration in cytosol will

A

decrease due to blockage of InsP3 gated channel on endoplasmic reticulum

B

decrease due to blockage of InsP3 gated channel on plasma membrane

C

increase due to efflux of Ca⁺² from InsP3 gated channel on mitochondria

D

increase due to efflux of Ca⁺² from InsP3 gated channel on endoplasmic reticulum as well as influx of Ca⁺² from InsP3 gated channel on plasma membrane

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18

2020 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2020

Which one of the following hormones initiates a signaling cascade by directly binding to an intra-cellular receptor?

A

Insulin

B

Gonadotropin

C

Progesterone

D

Epinephrine

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19

2020 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2020

Visual signal transduction cascade is activated by rhodopsin and involves degradation rather than synthesis of which ONE of the following second messenger molecules?

A

cAMP

B

IP3

C

cGMP

D

DAG

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20

2023 · Life Sciences · Cell Structure and Function · Cell Signalling and Receptors

Life Sciences (XL) 2023

Which of the following molecules is/are second messenger(s) produced by the phosphoinositide signaling cascade?

A

Phosphatidylinositol 4,5-bisphosphate

B

Inositol 1,4,5-triphosphate

C

Inositol 1,3,5-triphosphate

D

Diacylglycerol

Check answer

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