Immunology - General Biology - Biotechnology Previous Year Questions

1

2013 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2013

Endogenous antigens are presented on to the cell surface along with

A

MHC-II

B

MHC-I

C

F_cγreceptor

D

complement receptor

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2

2014 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2014

Reactions between antibodies and antigens that are detected by precipitate formation in an agar gel are referred as

A

immunoprecipitation assay

B

immunodiffusion assay

C

immunoaggregation assay

D

immunofixation assay

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3

2014 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2014

Match the immunoglobulin class in Group I with its properties in Group II

A

P-4, Q-1, R-2, S-3

B

P-3, Q-2, R-1, S-4

C

P-4, Q-3, R-1, S-2

D

P-1, Q-4, R-3, S-2

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4

2016 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2016

Find the INCORRECT combination.

A

Surface immunoglobulins – B cell antigen receptor

B

Affinity maturation – isotype switching

C

Fc region of antibodies – binding to complement proteins

D

Spleen, the secondary lymphoid organ – no connection with the lymphatic system

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5

2017 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2017

Which one of the following mechanisms is used by human pathogens to evade host immune responses?

A

Somatic hypermutation

B

Antibody production

C

Antigenic variation

D

Complement activation

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6

2017 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2017

Macrophages eliminate pathogenic bacteria upon activation by

A

NK cells

B

basophils

C

CD4+ T cells

D

plasma cells

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7

2017 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2017

An immunocompetent person becomes infected with a pathogenic strain of bacteria. Which one of the following graphs correctly depicts bacterial load in this person over time?

A

Graph A

B

Graph B

C

Graph C

D

Graph D

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8

2017 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2017

Which of the following conditions promote the development of human autoimmune disorders?
P. Inability to eliminate self-reactive lymphocytes
Q. Generation of auto-antibodies
R. Ability to eliminate self-reactive T-cells
S. Induction of regulatory T-cells in the thymus

A

P, R

B

Q, S

C

P, Q

D

R, S

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9

2018 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2018

Which one of the following is NOT a principal component of innate immunity?

A

Mucosal epithelia

B

Dendritic cells

C

Complement system

D

Memory B-cells

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10

2018 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2018

Which of the following cytokines are endogenous pyrogens?
P. Tumor necrosis factor-\(\alpha\)
Q. Interleukin-1
R. Transforming growth factor-\(\beta\)
S. Interleukin-10

A

P and Q only

B

P and R only

C

R and S only

D

Q and S only

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11

2018 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2018

Which one of the following amino acids is catalyzed by activated macrophages to produce reactive nitrogen species?

A

Arginine

B

Asparagine

C

Cysteine

D

Histidine

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12

2018 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2018

Which one of the combinations of the following statements is true about antibody structure?
P. Limited proteolysis of rabbit IgG with the enzyme pepsin generates two antigen-binding regions (Fab) and an Fc fragment
Q. Limited proteolysis of rabbit IgG with the enzyme papain generates a single bivalent antigen-binding region F(ab')\(_2\) and peptide fragments
R. The Fc fragment of IgG can self-associate and crystallize into a lattice
S. The F(ab')\(_2\) fragment of IgG is composed of both light and heavy chains

A

P and Q only

B

P and R only

C

R and S only

D

Q and S only

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13

2019 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2019

Which one of the following is NOT a part of the human nonspecific defense system?

A

Interferon

B

Mucous

C

Saliva

D

Antibody

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14

2020 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2020

Which of the following statements about immune response are CORRECT?
[P] T cells are activated by antigen-presenting cells
[Q] Foreign peptides are not presented to helper T cells by Class II MHC proteins
[R] Dendritic cells are referred to as professional antigen-presenting cells

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15

2021 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2021

Match the autoimmune diseases in Group I with the corresponding primarily affected organ in Group II.

Group I	Group II
P. Hashimoto's disease	1. Brain
Q. Juvenile diabetes	2. Pancreas
R. Multiple sclerosis	3. Skeletal muscle
S. Myasthenia gravis	4. Thyroid

A

P-1, Q-2, R-3, S-4

B

P-3, Q-1, R-2, S-4

C

P-4, Q-2, R-1, S-3

D

P-1, Q-2, R-4, S-3

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16

2021 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2021

Match hypersensitivity types in Group I with their corresponding condition in Group II.

Group I	Group II
P. Type I	1. Erythroblastosis fetalis
Q. Type II	2. Host reaction to bee venom
R. Type III	3. Systemic lupus erythematosus
S. Type IV	4. Tuberculin reaction

A

P-2, Q-3, R-1, S-4

B

P-3, Q-1, R-4, S-2

C

P-2, Q-3, R-4, S-1

D

P-2, Q-1, R-3, S-4

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17

2022 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2022

Match the cell type (Column I) with its function (Column II).

Column I	Column II
P. B cells	1. Humoral immunity
Q. Neutrophils	2. Cytotoxicity
R. T cells	3. Histamine-associated allergy
S. Mast cells	4. Phagocytosis

A

P-1, Q-2, R-3, S-4

B

P-1, Q-4, R-2, S-3

C

P-4, Q-3, R-1, S-2

D

P-4, Q-3, R-2, S-1

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18

2023 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2023

Match the immune tolerance mechanisms in Group I with their respective outcomes in Group II.

A

Group I	Group II
P. Anergy	1. Elimination of activated T-cells after antigen clearance
Q. Activation-induced cell death	2. Inhibition of auto-reactive T-cells at periphery
R. Receptor editing	3. Unresponsiveness to antigens due to lack of co-stimulatory molecules
S. Regulatory T-cells	4. Elimination of auto-reactive B-cells

B

P-3, Q-1, R-4, S-2

C

P-4, Q-3, R-1, S-2

D

P-3, Q-4, R-2, S-1

E

P-3, Q-2, R-4, S-1

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19

2024 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2024

2-mercaptoethanol breaks the ______ covalent bond between light and heavy chains of an immunoglobulin molecule.

A

N

B

N-O

C

S-C

D

S-S

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20

2024 · Biotechnology · General Biology · Immunology

Biotechnology (BT) 2024

If a denatured protein of human origin is injected into a rabbit, antibodies generated will recognize the ______ structure of the protein.

A

primary

B

secondary

C

tertiary

D

quaternary

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