Biomaterial Classes and Implant Compatibility - Biomaterials and Tissue Engineering - Biomedical Engineering Previous Year Questions

1

2020 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2020

Biomaterials with shape memory effects are NOT used in

A

Intracranial aneurysm clips

B

Arterial blood vessel closure devices

C

Orthopedic total joint replacements

D

Orthodontic dental arch wires

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2

2021 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2021

Which of the following may cause failure of bone implants?

A

Stress shielding – reduction of bone density due to removal of a typical stress from bone by an implant

B

Aseptic loosening – loss of bond between bone and implant in the absence of an infection

C

Fretting fatigue – progressive deterioration of material by small scale rubbing

D

Osseointegration – formation of a direct interface between an implant and a bone, without intervening soft tissues

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3

2022 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2022

An ideal coronary stent should

A

be thromboresistant

B

promote accumulation of smooth muscle cells

C

be fatigue resistant

D

support deposition of extracellular matrix

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4

2022 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2022

Which of the following mechanical prosthetic valves were invented as a replacement for diseased heart valves?

A

Globe valve

B

Ball and cage valve

C

Bi-leaflet valve

D

Swing check valve

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5

2022 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2022

Based on the stress-strain curves of three different materials (X, Y, and Z) shown in the figure, which one of the following choices is CORRECT?

A

X – Titanium, Y – Hydroxyapatite, Z – Polyethylene

B

X – Hydroxyapatite, Y – Titanium, Z – Polyethylene

C

X – Hydroxyapatite, Y – Polyethylene, Z – Titanium

D

X – Polyethylene, Y – Titanium, Z – Hydroxyapatite

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6

2023 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2023

Choose the option that has the biomaterials arranged in order of decreasing tensile strength.
(PMMA : poly-methyl-methacrylate)

A

Human compact bone > PMMA bone cement > Polymer foams > Graphite-epoxy

B

Human compact bone > Graphite-epoxy > PMMA bone cement > Polymer foams

C

Graphite-epoxy > Human compact bone > PMMA bone cement > Polymer foams

D

PMMA bone cement > Human compact bone > Polymer foams > Graphite-epoxy

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7

2023 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2023

A water insoluble polymeric biomaterial can become water soluble in vivo by which of the following mechanisms?

A

Cleavage of crosslinks between water soluble polymer chains

B

Cleavage of side chains leading to formation of non-polar groups

C

Cleavage of backbone linkages between polymer repeat units leading to the formation of polar groups

D

Enzymatic degradation of crosslinks between water soluble polymer chains

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8

2024 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2024

Bioglass 45S5 has a composition of ______.

A

45 wt% SiO₂ and 5:1 molar ratio of Calcium to Phosphorus.

B

45 wt% Hydroxyapatite and 5 wt% SiO₂.

C

45 wt% Hydroxyapatite and 5:1 molar ratio of CaO and Ca₃(PO₄)₂.

D

45 wt% SiO₂ and 5 wt% Hydroxyapatite.

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9

2024 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2024

Which one of the following drug release kinetic curves will be ideal for developing an implantable slow-release drug delivery device?

A

B

C

D

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10

2024 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2024

Bioglass 45S5 has a composition of ________.

A

45 wt% SiO\(_2\) and 5:1 molar ratio of Calcium to Phosphorus.

B

45 wt% Hydroxyapatite and 5 wt% SiO\(_2\).

C

45 wt% Hydroxyapatite and 5:1 molar ratio of CaO and Ca\(_3\)(PO\(_4\))\(_2\).

D

45 wt% SiO\(_2\) and 5 wt% Hydroxyapatite.

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11

2024 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2024

An orthopaedic implant when monitored over 6 months showed the following normalized curves for polymer molecular weight (MW), mass of implant and mechanical strength. Among the choices, what is the most probable reason for the observed changes?

A

Bulk erosion

B

Surface erosion

C

Bulk initially followed by surface erosion

D

No erosion but mechanical breakage due to injury

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12

2024 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2024

In an attempt to integrate engineered tissue with native tissue, three samples of engineered tissue, X, Y, Z, with identical material properties, were co-cultured adjacent to three different native tissues (bone, cartilage and liver). The adhesive strengths of X, Y, Z were observed after 8 weeks as follows. Adhesive strength for X = 150 kPa, Y = 250 kPa, Z = 350 kPa Match the native tissue that were used to co-culture X, Y and Z from the following. I: Liver Tissue II: Articular Cartilage III: Devitalized Bone

A

X with I, Y with II and Z with III

B

X with II, Y with III and Z with I

C

X with I, Y with III and Z with II

D

X with III, Y with II and Z with I

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13

2025 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2025

\({}_6^9\text{C}\) and \({}_6^{10}\text{C}\) are ____________, whereas \({}_6^9\text{C}\) and \({}_5^9\text{B}\) are ____________.

A

isotopes; isomers

B

isomers; isotopes

C

isotopes; isotones

D

isotones; isotopes

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14

2025 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2025

In the context of temperature sensitive polymers, LCST stands for ____________.

A

Large Critical Solution Temperature

B

Local Critical Solute Temperature

C

Large Critical Solvent Temperature

D

Lower/Lowest Critical Solution Temperature

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15

2025 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2025

Gelatin solutions P and Q of concentrations 3.5% and 0.5%, respectively, need to be mixed to obtain a 3% solution R. How much volume (in ml) of P needs to be mixed with 100 ml of Q to obtain R? (Choose the correct option)
All concentrations are in units of weight/volume.

A

100

B

250

C

500

D

1000

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16

2026 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2026

Which one of the following is not a polymer?

A

DNA

B

Albumin

C

Cholesterol

D

Dextran

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17

2026 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2026

Electrostatic interaction between a positively charged polymer and a negatively charged polymer in an aqueous medium most likely results in the formation of a ______________.

A

chemical-crosslinked hydrogel

B

complex coacervate

C

photo-crosslinked hydrogel

D

liposome

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18

2026 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2026

A drug is loaded in a polymeric device through a process. Which one of the following ratios defines the drug encapsulation efficiency of this process?

A

\(\frac{\text{Amount of drug successfully loaded}}{\text{Amount of polymer in the device}}\)

B

\(\frac{\text{Amount of drug successfully loaded}}{\text{Amount of drug used in the process}}\)

C

\(\frac{\text{Amount of drug used in the process}}{\text{Amount of drug successfully loaded}}\)

D

\(\frac{\text{Amount of polymer in the device}}{\text{Amount of drug used in the process}}\)

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19

2026 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2026

Which one of the following complement system pathways is most likely to be activated on biomaterials implanted in a healthy human?

A

classical pathway

B

lectin pathway

C

alternative pathway

D

extrinsic pathway

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20

2026 · Biomedical Engineering · Biomaterials and Tissue Engineering · Biomaterial Classes and Implant Compatibility

Biomedical Engineering (BM) 2026

Choose one of the following options that correctly fills the blanks labelled as I and II in the paragraph below.

Lower critical solution temperature (LCST) polymers exhibit a decrease in their water solubility with an increase in temperature. This happens because, at low temperatures, the hydrogen bonding between the ___I___ segments of polymer chain and the water molecules dominates. At high temperatures, the interactions between the ___II___ segments dominate.

A

I-hydrophilic; II-hydrophobic

B

I-hydrophobic; II-hydrophilic

C

I-hydrophilic; II-polar

D

I-hydrophobic; II-polar

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